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2.3.4 Bone remodeling balance regulatory pathway The RANKL/OPG pathway serves a crucial regulatory role in the differentiation and activation of osteoclasts, with its ratio being a significant determinant of bone integrity and mass (47)

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In addition, the clearance of apoptotic trophoblasts causes the IL-10 production, and suppression of inflammatory cytokines by macrophages, suggesting that efferocytosis plays an important role in maternal-tolerance [23], while in the post-lactation apoptotic cell clearance at the mammary gland drives tissue remodeling [24]

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